Generative AI Startups funded by Y Combinator (YC) 2026

What your best people know, every agent in your org can use. Glen picks it up as the work happens, nothing to write down, nothing to maintain, and it never walks out the door. A day-one hire's agent runs on the same judgment as your most senior person's.

Ritivel is an AI-native workspace for regulatory and medical writing teams at life sciences companies. Our AI agents draft CTDs, CSRs, INDs, and BLAs in minutes instead of weeks, helping drugs reach patients faster. Every month a drug is delayed from reaching the market costs pharma companies ~$45M in lost revenue and more importantly, delays treatment for thousands of patients who need it. Yet regulatory teams are stuck in a painful, months-long process: synthesizing thousands of pages of clinical data, hunting through SharePoint folders for the right documents, chasing colleagues for missing inputs, and manually drafting submissions. Ritivel deploys AI agents that transform how regulatory teams work. Our agents generate comprehensive first drafts directly in Microsoft Word, following FDA formatting requirements and pulling from your existing clinical data and prior submissions. Every data point includes citations linked back to the original source, so reviewers can verify with one click. Connected to SharePoint and Veeva, our agents automatically source the right documents. Integrated with Outlook, they handle reminder emails and follow-ups automatically. We're engineers who previously built AI copilots at Microsoft Research. After 50+ conversations with pharma professionals, we discovered the critical bottleneck in regulatory submissions and built Ritivel to solve it.

Anto is building a foundation model for microbial communities, making the gut microbiome computable for the first time. We predict drug toxicity and efficacy across diverse populations and fix drugs so they work for everyone — solving the hidden root cause of most drug failures. Founded by Arvid (Broad Institute of MIT and Harvard; Nature-published researcher who pioneered quality-aware, goal-directed sparsification) and David (Harvard Medical School Gastroenterology, J&J), second-time founders who published the breakthrough at leading machine learning AI conferences and Nature.

Bringing data realism to frontier models.

Expected Parrot helps companies simulate their customers with AI agents to explore pricing, product, marketing, communications and other scenarios at scale. Our open-source library and no-code web app let you design custom agent personas and conduct interviews and surveys with them using LLMs of your choice to generate results and reports. Everything is cached and reproducible, and you can send the same surveys to human respondents to validate results in the same interface.

Absurd makes AI brand and performance ads at scale. Our last video for Kalshi ("Election Day") did 1M+ views, and our videos average 400K+ organic views. Companies like Hims, Kalshi, Replit, and Brex use Absurd to create production-quality videos in 72 hours. Try it at absurd.com

LunaBill is building AI Voice callers for healthcare billing teams. Insurance claim follow-up calls account for the 80% of the daily workload of a healthcare billing team, with each call averaging 30 minutes. Since our launch in July we are now at $764K in contracted ARR, of which $428K is live revenue and the rest will go live by January 2026. Our customers see a 10x increase in claims followed up per biller in the first week and we have converted 100% of pilots to paying customers. We have automated 50,000+ calls and signed partnerships with top healthcare leaders like UC health systems, Mayo, Experian Health and more. The founders have known each other for over a year. Suhail is a 2x founder, with 3+ years of experience building in healthcare including operating a medical billing company with 200+ healthcare clients. David founded Skiesoft, Taiwan’s biggest healthcare AI scribe company, used by 120k+ healthcare professionals. He also worked as a data scientist at UCSF, building models to audit medical-coding accuracy. Yash was a researcher at various hospital systems including Mayo Clinic.

Pixley turns kids' drawings and ideas into fully animated cartoons – in minutes. Kids are natural storytellers. With Pixley, any kid can draw a character, describe a world, and watch their story come to life as a personalized animated cartoon. Most kids' screen time is broken: passive, algorithmic content designed to keep kids watching, not growing. Pixley is the antidote. Every episode is safe, ad-free, and built around Social-Emotional Learning (SEL). Parents can choose any lesson they want to teach their child, and Pixley weaves it naturally into the story their kids create. We're building the creative platform for the next generation – where kids are the directors, not just the audience. Additionally, the same technology powers Pixley Studios, our B2B content service for brands and content creators who want to produce high-quality AI video without the cost or time of traditional production. We’re 19 year old CS dropouts who’ve known each other since elementary school and won 4 hackathons at 15. After seeing AI flood the internet with low-quality content, we created Pixley – a safe, personalized way for kids to turn their ideas into animated stories.

Koyal is an Agentic AI Filmmaking Platform that allows you to seamlessly convert script or audio into personalized, visually compelling stories. We’re a team from Carnegie Mellon, MIT and Meta, with experience in AI video generation. https://koyal.ai builds directly upon our published research at the AI conference NeurIPS in December. We’ve been covered in the international press for our patented secure personalization protocol CHARCHA: the genAI captcha. Announcement: https://x.com/meh_agarwal/status/1965866965425348687 Demo: https://x.com/meh_agarwal/status/1965137062119752099 We currently have paid pilots with the biggest global music labels, podcasts and production houses, and just launched our public beta at beta.koyal.ai We recently concluded a pilot with Universal Music and T-Series (world’s largest music label) alongside Bollywood production houses like Maddock Entertainment, and Collective Artists Network! As part of that, we launched 5 music videos for Grammy and Oscar winning artists like A R Rahman, Ricky Kej and Shankar Mahadevan all crossing 1.5 million views! We've recently built SOTA capabilities in (i) multilingual script to audio to video, (ii) Agentic lip-sync with dynamic movement & (iii) Multi-character consistency.

Specific builds audio and enterprise datasets representative of work inside real-world businesses. The next frontier of AGI is bottlenecked by data that is hard to access, and we make that easier.

Bezel helps fashion brands create virtual photo/video shoots with AI. Upload images of clothes, select the human you want to model it, and Bezel generates pictures and videos that rival a full studio production. Every detail of the clothing is rendered flawlessly. Try it for yourself.

Automatic insights on all your company data. Speed up business workflows to visualizations with a 0 learning curve.

Knowlify makes it easy for companies to create animated explainer videos using AI. Upload any document and/or prompt deck to get a professional explainer video in minutes - no designers, animators, or video editors needed. Teams use Knowlify to produce training videos, customer literacy videos, product explainers, onboarding content, and internal communications at a fraction of the traditional cost and timeline. Available as a self-serve platform or a fully managed service.

Doe is where AI agents actually do your work. Connect your tools, tell Doe what you need, and agents handle it. When you want to do something yourself, Doe makes you faster and smarter. The boring stuff disappears. Everything else gets better.

Kashikoi is a simulation engine to benchmark AI agents. We generate CPU friendly world models that autonomously interview agents and generate deep behavioral assessments. We built a similar technology at Moveworks which was used to ship 250+ enterprise agents to customers daily.

The LLM Data Company is training models in data scarce verticals

Cohesive is the agentic CRM for blue collar businesses like janitorial, pressure washing, landscaping, HVAC, and pest control businesses. Cohesive fully automates sales and marketing outreach to local businesses and property owners in the service area, helping local service businesses grow even while servicing clients in the field.

Blueshoe is an AI platform for legal research and reasoning designed to capture the structure of legal thought and allow users to work directly within the logic of caselaw. By combining advanced AI with curated legal and proprietary data pipelines, the system allows users build and test arguments with unprecedented clarity.

Auctor brings alignment and intelligence to software implementation, enabling every project to deliver its intended value with clarity and precision.

Dollyglot is like Character.ai but with real time video avatars. Turn a photo and a voice into a real friend. Speak with Harry Potter about Hogwarts or brainstorm ideas with Elon Musk!

AI creative tools became powerful quickly. But they also got complicated. Most of them require creatives to do the engineering. Prompts. Parameters. Node graphs. Creative work doesn’t start there. It starts with thinking, exploring directions, and iterating on ideas. With Awen, we’re trying a different approach: A creative partner that turns intent into exceptional visuals through conversation.

Tergle builds AI to replace Auditors.

Truffle AI makes it easy for developers to integrate AI agents into any software application. We do this by exposing agents as simple APIs that can be called from anywhere. Developers have used Truffle to add customer support agents into WhatsApp and analytics agents into Slack.

Emergent builds autonomous coding agents that replace traditional software development by generating, testing, and deploying production applications directly from plain-language intent. Our systems run in production at global scale and are used to build millions of real applications. Since our public launch, Emergent has reached $50M ARR in 7 months making us one of the fastest-growing startups in the world. 5M+ users across 190+ countries have built 6M+ applications on Emergent. We've raised $100M from Khosla Ventures, SoftBank, Google, Lightspeed India, Prosus Ventures, Together Fund, and Y Combinator.

assistant-ui helps frontend developers add AI chat to their apps. Our product is used by several dozen companies, like LangChain, Stack AI, Browser Use, and Athena Intelligence. We're building an open source Typescript/React library and a backend as a service, with first class integrations into popular agent frameworks like LangGraph and Vercel AI SDK.

TrainLoop makes it effortless for developers to supercharge LLM performance through reinforcement learning.

Wildcard is the AEO and GEO platform designed specifically for e-commerce and retail brands. We help merchants improve visibility across AI search and AI shopping platforms like ChatGPT, Google AI Overviews, Gemini, and Amazon Rufus. Wildcard tracks how brands, categories, collections, and SKUs appear across AI search results, identifies visibility gaps, and turns those insights into actions. We use AI agents to enrich product data, generate SEO, AEO, and GEO content, create collection and comparison pages, build FAQs, and improve off-site discoverability across Reddit, YouTube, blogs, and other sources. As AI shopping evolves, Wildcard is building the infrastructure brands need to win in agentic commerce, including support for emerging standards like the Agentic Commerce Protocol (ACP) and Universal Commerce Protocol (UCP).

Calltree makes enterprise-grade AI support reps for call centers. Our AI reps take voice calls and chats like other AI support agents but can also use internal enterprise tools like a homegrown CRM or internal dashboards, like the highly trained humans working there today.

Trava is building AI agents for global trade compliance. Importers lose billions each year to duty overpayments and filing errors. Trava audits customs entries and automates classification to help importers protect margins and stay compliant at scale.

Sennu AI builds AI systems that fundamentally transform how your business operates

City building departments are understaffed and overworked. Meanwhile, builders lobby to remove power from building departments. Because building departments are usually the only profitable/self-sustaining branch of a local government, this is problematic. Permitify allows city build-plan reviewers to 10x their productivity covering the labor shortage, reducing the time required to issue a building permit, and allowing the city government's only profitable branch to stay intact.

a0.dev is a platform that helps mobile developers build high quality apps in days instead of weeks by generating custom react native projects. We've launched top ranking apps that have been used by hundreds of thousands, and now we're creating the tools we wish we had to build faster.

Alice turns generic course materials into personalized learning and exam prep using AI. We’re Duolingo for exams, and more than 10k college students have already used Alice. Kim, the CEO, is a domain expert in education with more than 10+ years of university teaching experience. He is also technical by background. MRR is $20k, growing +10% week-over-week the last 8 weeks Alice's core market opportunity is +$10b, with the global education market being almost $10trillion. As AI starts to disrupt education, Alice will use in-built network effects and virality in its product to create a global winner. Go Alice. Thank you!

Confident AI allows companies of all sizes to benchmark, safeguard, and improve LLM applications, with best-in-class metrics and guardrails powered by DeepEval. Built by the creators of DeepEval (12.6k stars, >3m monthly downloads), Confident AI is able to offer battle-tested, open-source evaluation algorithms while providing the infrastructure needed for teams to stay confident their LLM systems.

Docs are integral to a great customer experience, but managing them is a challenging, multi-team effort. The most successful companies recognize that fantastic docs drive adoption and bad ones cause customers to churn. Promptless is used by fast-growing startups and Fortune 500 enterprises alike to automatically update docs based on feature releases, support tickets, internal Slack conversations, and more. Promptless is designed to be flexible—it can integrate with any docs platform, be triggered automatically from many workflows, and can pull in context from any internal knowledge source. With Promptless, documentation becomes a strategic advantage for growth, not a bottleneck or a liability.

x1 is an AI app builder that helps anyone create real, App Store-ready iOS apps. Users start with a structured product plan, design polished iPhone screens in a visual canvas, build features step by step, and prepare launch assets like App Store listings, screenshots, monetization, and analytics. Instead of generating one-shot AI demos, x1 gives builders a guided system for turning an idea into a real app.

Pearson builds AI agents to automate corporate transactions. Large law firms use us to run gigantic books of businesses with AI, reducing their cost of delivery 40-60%.

Endstack is a desktop OS optimized for humans and agents running in the cloud. Your desktop is powered by endOS, giving you a real desktop workspace in the browser backed by Linux in the cloud. Files, notes, browser tabs, native apps, terminals, and all your agents in one beautiful, familiar, interface. You get a powerful agent running 24/7, integrated at the system level into endOS that you can also reach via Slack, email, or SMS. Endstack desktops are also natively multiplayer, allowing for realtime collaboration with teammates.

Kura breaks 87% on the WebVoyager Benchmark. That is 31% better than Claude's Computer Use demo and 14% better than the previous State of the Art. In 10 years there will be more AI agents on the internet than humans. Kura is SOTA for giving AI agents the tools for interacting with websites.

Melder is an Excel add-in that brings AI functions and document support into your spreadsheets. Upload files directly into cells, use smart formulas like =GEN, and build automations—all without leaving Excel. Core features: - File-to-Sheet: Drop PDFs directly into cells, then reference them in formulas. - AI-Powered Functions: Write formulas like =GEN() or =EXTRACT() to summarize, classify, and analyze content. - Chat Assistant: Use our AI assistant to help build your sheets or answer questions from your data, live in the workbook. Business users use Melder to: - Accelerate diligence by extracting insights from data rooms - Review contracts by identifying key terms and clauses instantly - Run market research by pulling information from competitor websites - Synthesize transcripts by generating summaries from interviews and calls Melder brings the power of structured spreadsheet logic to the messy, unstructured data world—no coding needed.

Reticular is scaling polygenic prediction for embryo selection, helping IVF couples plan their families today while building a platform to unlock cures for complex heritable diseases long-term. John competed Biology Olympiads before spending 4 years at MIT publishing ML/bio research in NeurIPS and Nature. We believe biological models encode far more information than anyone is currently using - our goal is to unlock this potential.

ISSEN is an AI conversational language app that helps you become fluent. Your on-demand voice tutor is personal to you, adapting lessons and chats to your particular interests, learning style, and goals. Our mission is to transform language learning by offering a level of connection, effectiveness and fun that, until now, only human teachers could provide.

camfer is the AI CAD tool. Now, engineers can create parametric designs with natural language.

Unsloth helps builders create custom models better & faster using RL and custom kernels. We're developing the all in one solution to help you create highly-accurate custom models 30x faster with 90% less memory use. With over 10 million monthly model downloads and 40K GitHub stars, our mission is to make training and open-source the best it can be!

AI entertainment feels like slop because companies bet on technology instead of people. Companies chase tech because it usually lets them win. But what fans love has never been about the tech. A fan doesn’t fill their apartment with posters because of the lens a movie was shot on. They do it because of the mind behind the camera. AI is a power-up. In the wrong hands, more and more of what you see becomes sludge. In the right ones, the good stuff wins. DreamRP builds for creatives, from indie artists to global stars, because they’ve always been the real reason fans love what they love. If you get it, message me why.

MagiCode is an AI-powered frontend agent that writes, reviews, and rigorously tests code before pushing a PR—helping busy frontend teams offload complex, repetitive tasks from their workload.

At Redouble AI we have developed Silverlake, a Java-native agentic AI operating system for enterprise. While other AI solutions force enterprise stakeholders to embrace unfamiliar concepts in an unfamiliar language, we do the opposite: we slot agentic AI right into the enterprise comfort zone - by mapping all agentic concepts onto established enterprise primitives in their own language, their own security model, their own infrastructure. It’s like moving from Bitcoin to Stablecoin, just for agentic AI. When we did YC we realized there was no framework or platform that gave us as enterprise and workflow automation veterans what we needed to build truly secure, reliable, and scalable agentic solutions for mission-critical workflows. That’s why we spent the past 18 months building Silverlake from the ground up. We empower the 12 million Java engineers worldwide to write and deploy their own AI, securely, at scale. They define an agent in a few lines of code, and our platform does everything else, from orchestration to permission control, from auditability to rate limiting, from long-running agents to autonomous coordinated networks that perform the work of entire departments. Silverlake has been developed with design partners across biopharma, insurance and financial services. For example, our agentic workflows write submission-ready Clinical Study Reports that are hundreds of pages long, analyze entire datarooms full of financial and operational data for private equity investors, and automate claims processing for a large insurance player. We are backed by Y Combinator, Exponential, Transpose Platform, Tiny VC, and the Oxford Seed Fund and advised by Java inventor James Gosling and automation guru Professor Christian Terwiesch.

Generate. Paint. Refine. ideate.xyz is an AI-powered 3D art suite on the web, taking your ideas from concept to production ready assets in record time. Our powerful text to image to 3D pipeline rapidly generates model assets using the latest AI tech. Rapidly generate and edit 3D model textures in your browser using our texture projection and inpainting editor. Get your 3D assets production ready using our texture processing, upscaling and compression algorithms.